A five-vehicle fatal collision on Interstate 10 north of Casa Grande closed all lanes east and westbound Thursday morning, according to the Department of Public Safety.
Shortly after 5:15 a.m., a westbound semi truck crossed over the median and crashed head-on into an eastbound vehicle, said Tim Case, a Department of Public Safety spokesman.
The driver of that second vehicle died.
The investigation into the cause of the collision is ongoing, Case said.
Investigators could not provide any additional information on injuries other than the fatality.
Helicopter footage from the scene showed a semi toppled on its side as it sat on the shoulder of the road and faced oncoming traffic.
One alternate route from Phoenix to Tucson includes taking State Route 87 to State Route 187. Drivers will then return to I-10 just north of Casa Grande.
Another option, provided by ADOT, is exiting at State Route 347 and travelling through Maricopa.